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Ihde and Konstantinovic (2007) performed a systematic search of the literature to identify RCTs evaluating patients treated with botulinum toxin as an adjunct to dental implant therapy, maxillofacial conditions including temporo-mandibular disorders (TMD), and cervical dystonia.

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Autonomic side effects were observed in 4 patients.

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After a median of 32 (range 14--67) weeks' follow-up following completion of treatment, 27 of 41 patients available remain symptom free.

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They stated that continued research may lead to more specific and reliable treatment for Raynaud's patients.

Your doctor will usually diagnose an anal tear (fissure) by your typical symptoms and by examining the skin around your back passage (anus).

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After 6 weeks the treatments were crossed over without washout in line with previous findings.

The following information is NOT intended to endorse drugs or recommend therapy.

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BTX-A may be associated with improvement in the frequency of chronic migraine, but the association of BTX-A with clinical benefit was small (Jackson et al, 2012).

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Canadian Agency for Drugs and Technologies in Health (CADTH).

On the other hand, data on the use of botulinum neurotoxin for detrusor-sphincter dyssynergia (DSD) are conflicting.

It is injected directly into the internal anal sphincter, in effect performing a chemical sphincterotomy.

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Brien, 2014) and “Postconcussion syndrome” (Evans, 2014) do not mention the use of botulinum toxin.

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The authors concluded that botulinum toxin A infiltrations are a safe and useful treatment for patients with severe bruxism.

Even if it has lasted six weeks, technically becoming known as chronic anal fissure, there is still a reasonable chance that it will heal on its own without treatment.

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Cochrane systematic evidence review found that botulinum toxin may have a role in certain types of shoulder pain.

Treatment of children with cerebral palsy during the early years when functional skills in walking are being developed improves the outcome and may help to avoid surgery for contracture and bony torsion.

It was not possible to establish dose effect information.

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Data Sources: The following evidence-based medicine resources were searched using the key words stapled hemorrhoidopexy, hemorrhoidectomy, hemorrhoids, hemorrhoid treatment, rubber band ligation hemorrhoids, hemorrhoid surgery, hemorrhoids pregnancy, and thrombosed external hemorrhoids: Essential Evidence Plus, the Cochrane Database of Systematic Reviews, Pubmed, UpToDate, the National Guideline Clearinghouse, the Institute for Clinical Systems Improvement, and the Database of Abstracts of Reviews of Effects.

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In addition, both of the studies were short term, with no comparisons to other treatments for back pain.

It helped a lot, but the doctor recently upped my dosage to 180mg twice a day for chest pain that I am now experiencing from coronary spasms due to a myocardial bridge diagnosed via catheterization!

Only 1 of the 3 trials had a low risk of bias and demonstrated that BoNT injections reduced pain at 3 and 8 weeks and improved function at 8 weeks better than saline injections.

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One RCT in arthritis-related shoulder pain indicated that botulinum toxin reduced pain severity (MD -2.

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Surgical intervention is rarely required for acute fissures in children, and symptoms from an acute fissure often resolve within 10-14 days of conservative medical management.

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